Bioactive Peptides

Research Group “Bioactive Peptides”

Bioactive peptides are increasingly being studied in several areas, demonstrating the great potential of these molecules. The enormous versatility in terms of structure and function of these biomolecules allows their rational design, necessary for the development of new therapeutic peptides. It is intended in this group, to develop activities of design, synthesis and studies of structure-function of peptides with therapeutic potential. Different molecules with antibacterial, antiviral, healing activities, among others, are the object of study.

Group responsible: Professor Esteban Nicolás Lorenzón - E-mail: estebanlorenzon@hotmail.com

Latest achievements:

- LORENZÓN, E. N; PICCOLI, J. P.; SANTOS-FILHO, N. A.; CILLI, E. M. Dimerization of antimicrobial peptides: a promising strategy to enhance antimicrobial peptide activity. PROTEIN AND PEPTIDE LETTERS, v. 26, p. 1-10, 2019.

- DE FREITAS, LAURA MARISE ; LORENZÓN, ESTEBAN NICOLÁS ; SANTOS-FILHO, NORIVAL ALVES ; ZAGO, LUCAS HENRIQUE DE PAULA ; ULIANA, MARCIANA PIERINA ; DE OLIVEIRA, KLEBER THIAGO ; CILLI, EDUARDO MAFFUD ; FONTANA, CARLA RAQUEL . Antimicrobial Photodynamic therapy enhanced by the peptide aurein 1.2. Scientific Reports, v. 8, p. 1-15, 2018.

- LORENZÓN, ESTEBAN N.; NOBRE, THATYANE M.; CASELI, LUCIANO; Cilli, Eduardo M.; DA HORA, GABRIEL C.A.; SOARES, THEREZA A.; OLIVEIRA, OSVALDO N. The -pre-assembled state- of magainin 2 lysine-linked dimer determines its enhanced antimicrobial activity. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 167, p. 432-440, 2018.

- DE FREITAS, LAURA MARISE; LORENZÓN, ESTEBAN NICOLÁS; CILLI, EDUARDO MAFFUD; DE OLIVEIRA, KLEBER THIAGO; FONTANA, CARLA RAQUEL; MANG, THOMAS S. Photodynamic and peptide-based strategy to inhibit Gram-positive bacterial biofilm formation. BIOFOULING, 2019